sickle-cell disease

1. Sickle-cell disease predominates in Africa.
   镰状细胞病主要见于非洲。
2. Poor blood oxygen levels and blood vessel blockages in people with sickle-cell disease can lead to chronic acute pain syndromes, severe bacterial infections, and necrosis ( tissue death).
   镰状细胞病患者血液含氧量低并且发生血管堵塞，可导致出现慢性和急性疼痛综合症、重度细菌感染和坏疽（组织坏死）。
3. Sickle-cell disease is characterized by a modification in the shape of the red blood cell from a smooth, donut-shape into a crescent or half moon shape.
   镰状细胞病的特征是红血球形状发生突变，由平滑的圆圈形状改变为新月形或半月形。
4. This has been done successfully in mice with sickle-cell disease, but will not be possible for some years in people.
   在患有镰刀形细胞症的实验鼠身上此法已获成功。但是，在未来几年，此法尚无法在人类患者身上实施。
5. One option in future may be to create stem cells from a patient's own tissue, then return these after using gene therapy to correct the genetic mutation that causes sickle-cell disease.
   未来一个选择是从患者的组织培养干细胞、经基因疗法纠正导致镰刀形细胞症的遗传变异后再移植给患者本身。
6. Likewise, in people with a genetic disorder such as sickle cell anemia, the new blood system would not have the sickle-cell mutation, eliminating the cause of disease.
   同样的，对于遗传疾病（如镰状细胞性贫血）患者，新造血系统不再有镰状红细胞变异，因此消除了该疾病的病因。
7. Sickle-cell disease and severe forms of thalassaemia ( thalassaemia major) can occur only when both parents are carriers of trait genes for the particular condition.
   只有当父母双方都携带特定疾病的特征基因时，才有可能发生镰状细胞病和严重的地中海贫血（重型地中海贫血）。

noun

1. a congenital form of anemia occurring mostly in blacks

   Synonym:    sickle-cell anemiasickle-cell anaemiacrescent-cell anemiacrescent-cell anaemiadrepanocytic anemiadrepanocytic anaemia